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Research Hypotheses

AAV packaging

Mini-STRC Hypothesis

Truncated STRC construct (3984 bp) for AAV delivery.
In situ correction

Prime Editing

Precision correction of c.4976A>C using PE3/PE3b.
Non-invasive

Sonogenetics

Mechanosensitive channel activation via focused ultrasound.
Sonoporation

Delivery

Non-invasive cochlear gene delivery via sonoporation + LNP.
Stochastic model

Dual-Vector vs Single-Vector

Poisson model of co-transduction probability cost.
Biophysics

Electrostatic Analysis

Coulomb energetics of E1659A adhesion interface.
Pharmacokinetics

Immune Response

NAb kinetics and delivery vehicle comparison.